Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection.
نویسندگان
چکیده
A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection.
منابع مشابه
Commercial antibody-based tests for diagnosis of acute Chikungunya infection.
We endorse the recommendations of Blacksell et al. (2) for the development of reliable, rapid, point-of-care commercial assay formats for Chikungunya virus (CHIKV) infections. Though the performances of both the Chikungunya IgM antibody rapid immunochromatographic test (ICT) device and a Chikungunya IgM antibody enzyme-linked immunosorbent assay (ELISA) manufactured by Standard Diagnostics (Sou...
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ورودعنوان ژورنال:
- Clinical and vaccine immunology : CVI
دوره 18 10 شماره
صفحات -
تاریخ انتشار 2011